Margaret E. Logan

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Margaret E. Logan

Emerita (2019)

Education

• PhD, Organic Chemistry, University of Rochester
• A.B., Brown University, magna cum laude, with honors 1976

Courses Taught

• Organic Chemistry I and II Lecture and Laboratory
• Advanced Organic Laboratory
• General Chemistry I and II Lecture and Laboratory

Research Interests

• SUNY College at Brockport, Brockport, New York Fall 2000 - present
  In collaboration with summer research students and students doing independent research projects, pursuing the synthesis and evaluation of novel diaryl telluride antioxidants, and the development of homogeneous catalytic systems for application to remediation of aryl chlorides such as PCB’s.
• Hobart and William Smith Colleges, Geneva, New York Winter - Spring 2000
  Supervised two students in independent research projects involving antioxidant synthesis and water-soluble dyes.
• Ortho-Clinical Diagnostics, Rochester, New York 1992 - 1998
  Principal Scientist: Developed new chemistry and materials for traditional clinical chemistry assays and immunoassays: dyes, ionophores, haptens, stabilizers.
• Eastman Kodak Company, Rochester, New York 1982 - 1992
  Senior Research Scientist: Collaborated with the Sterling-Winthrop Pharmaceutical Research Division in the design and synthesis of matrix metalloproteinase inhibitors and neurokinin receptor inhibitors. Designed and synthesized sensitizing dyes.
• Department of Chemistry, University of Rochester, Rochester, New York 1978 -1982
  Graduate Studies: Natural product total synthesis
• CIBA-Geigy, Cranston, Rhode Island 1976 - 1978
  Process Research Chemist: Process research and production support for the synthesis of pharmaceutical compounds.

• Awards/Recognitions
  • Chancellor’s Award for Excellence in Teaching (2006).
  • W. D. Walters Teaching Award, University of Rochester (1980).
  • Sherman Clarke Fellowship, University of Rochester (1978-1982).
• Recent Publications

  M. E. Logan and M. E. Oinen, “Dechlorination of Aryl Chlorides with Sodium Formate Using a Homogeneous Palladium Catalyst”, Organometallics 2006, 25, 1052-1054.

  M.R. Detty, M.E. Logan, “One and Two-Electron Redox Reactions in Organoselenides and Organotellurides”. In Advances in Physical Organic Chemistry, V. 39, J. Richard, Ed.; Academic Press: San Diego, 2004; pp. 79-145.

  M. E. Logan, J. Fyles, S. Hasselberg. US Patent 5928886 “Reduction in first slide bias and improved enzyme stability by incorporation of diaryl tellurides in the gravure layer of dry-film immunoassay elements” (1999).

  W. W. Weber, C. R. Messing, M. E. Logan, US Patent 5,747,345, “Calcium Specific Diaza-18-crown-6-ether Chromoionophores” (1998).

  M. E. Logan, C. A. DeCann, M. D. Bale, G. L. Snodgrass, R. E. Snoke, US Patent 5,686,254, “Reduction in First Slide Bias and Improved Enzyme Stability by the Incorporation of Diaryl Tellurides in Thin-Film Immunoassay Elements” (1997).

  A. K. Ghose, M. E. Logan, A. M. Treasurywala, H. Wang, R. C. Wahl, B. E. Tomczuk, M. R. Gowravaram, E. P. Jaeger, and J. J. Wendoloski, “Determination of Pharmacophoric Geometry for Collagenase Inhibitors Using a Novel Computational Method and Its Verification Using Molecular Dynamics, NMR, and X-ray Crystallography,” J. Am. Chem. Soc. 1995, 117, 4671-4682.

  M. R. Detty and M. E. Logan, “Isopentyl Nitrite,” In Encylopedia of Reagents for Organic Synthesis, L. A. Paquette, Ed, Vol 4, Wiley, New York: 1995, pp 2908-2911.

  K. B. Lawrence, B. R. Venepalli, K. C. Appell, R. Goswami, M. E. Logan, B. E. Tomczuk, and J. M. Yanni, ” Synthesis and Substance P Antagonist Activity of Naphthimidazolium Derivatives,” J. Med. Chem. 1992, 35, 1273-1279.

  B. R. Venepalli, L. D. Aimone, K. C. Appell, M. R. Bell, J. A. Dority, R. Goswami, P. L. Hall, V. Kumar, K. B. Lawrence, M. E. Logan, P. M. Scensny, J. A. Seelye, B. E. Tomczuk, and J. M. Yanni, “Synthesis and Substance P Receptor Binding Activity of Androstano[3,2-b](pyrimido[1,2-a]benzimidazoles),” J. Med. Chem. 1992, 35, 374-378.

  K. C. Appell, B. E. Babb, R. Goswami, P. L. Hall, K. B. Lawrence, M. E. Logan, R. Przyklek-Elling, B. E. Tomczuk, B. R. Venepalli, and J. M. Yanni, “Imidazo[4,5-b]-quinoxaline Cyanine Dyes as Substance P Antagonists,” J. Med. Chem. 1991, 34, 1751-1753.

  M. E. Logan, R. Goswami, B. E. Tomczuk, and B. R. Venepalli, “Recent Advances in Neurokinin Receptor Antagonists.” In Annual Reports in Medicinal Chemistry, V. 26; J. Bristol, Ed.; Academic Press: New York, 1991; pp 43-51.

  B. E. Tomczuk, M.E. Logan, R. Goswami, and B.R. Venepalli, “Neurokinin Receptor Ligands,”Current Opinions in Therapeutic Patents 1991, 1, 197-210.

  M. E. Logan, US Patent 4,839,260, “Novel Polymethine Dyes and UV Absorbers and Imaging Materials for Their Use” (1989).

  M. E. Logan, US Patent 4,839,274, “Novel Polymethine Dyes and UV Absorbers Containing a Triarylborylisocyano Group and Imaging Materials for Their Use” (1989).

  M. E. Logan, US Patent 4,855,213, “Novel Polymethine Dyes and Imaging Compositions” (1989).

  A. S. Kende, J.P. Rizzi, M. Logan King, “Stereospecific Total Synthesis of 11-Deoxyanthracyclinones.” In Anthracycline Antibiotics; J.S. El Khadem, Ed.; Academic Press: New York, 1982, pp 141-166.

  A. S. Kende, M. Logan King, D. P. Curran, “Total Synthesis of (+/-)-4’-Demethyl-4-epipodophyllotoxin by Insertion-Cyclization,” J. Org. Chem. 1981, 46, 2826-8.

• Presentations

  Margaret E. Logan, Synthetic and Mechanistic Aspects of Palladium-Catalyzed Reactions of Aryl Chlorides Rochester Institute of Technology (January 12, 2010). (Invited talk)

  Margaret E. Logan, Clickers in the General Chemistry Courses at SUNY Brockport, 20th Biennial Conference on Chemical Education, Richmond, IN, July 27-31, 2008. (Poster presentation)

  Margaret E. Logan, Cory J. Charbonneau, Mark E. Oinen, Palladium-Catalyzed Reactions of Aryl Chlorides in Ionic Liquids, 40th National Organic Symposium, Duke University, Durham, NC, June 3-7, 2007. (Poster presentation)

  Margaret E. Logan, Alicia M. Penna, Andrea N. Topolnycky, Ahmed Yimam, “The Synthesis And Antioxidant Properties of Electron-Rich Diaryltellurides,” Northeast Regional Meeting of the American Chemical Society, Rochester, NY (2004). (Poster Presentation

  Margaret E. Logan, “The Synthesis and Antioxidant Properties of Electron-rich Diaryl Tellurides,” Buffalo State College (September 23, 2004).

  Margaret E. Logan, Elizabeth A. Gregory, Stacy Morill and Andrea Topolnycky, “An Improved Synthesis of Electorn-Rich Diaryyl Ditellurides and Diaryl Tellurides”, 38th National Organic Symposium, in Bloomington, Indiana, June 8-12, 2003. (Poster presentation)

  M. E. Logan, E. A. Christensen, D. J. Ertl, I. B. Hamlet, Z. J. Henneman, “The Synthesis of Electron-Rich Diaryl Tellurides,” Northeast Regional Meeting of the American Chemical Society, Durham, NH (2001). (Poster presentation)

  M. E. Logan, K. A. Jackson, H. R. Luss, “Novel Heterocycles from Triarylborane-Isonitrile Complexes,” Rochester Institute of Technology (1989).

  M. E. Logan, “Novel Heterocycles from Triarylborane-Isonitrile Complexes, Gordon Research Conference on Heterocyclic Chemistry (1988).

  M. E. Logan, K. A. Jackson, H. R. Luss, “Novel Heterocycles from Triarylborane-Isonitrile Complexes,” Northeast Regional Meeting of the American Chemical Society, Rochester, NY (1987).

  Research Presentations by Undergraduate Collaborators

  Trevor O’Leary, Margaret E. Logan, Rey A. Sia, Synthesis and Evaluation of Telluride Antioxidants for the Study of Oxidatitve Damage to Mitochondrial DNA, 23rd National Conference on Undergraduate Research, La Crosse, WI, April 16-18, 2009 (Oral presentation)

  Trevor O’Leary, Margaret E. Logan, Rey A. Sia, Synthesis and Evaluation of Telluride Antioxidants for the Study of Oxidative Damage to Mitochondrial DNA, 54th Annual Undergraduate Research Symposium of the Rochester Section of the American Chemical Society, St. John Fisher College, Rochester, April 25, 2009. (Oral presentation)

  Trevor O’Leary, Margaret E. Logan, Rey A. Sia, Synthesis and Evaluation of Telluride Antioxidants for the Study and Prevention of Oxidative Damage to Mitochondrial DNA, Rochester Academy of Science Fall 2008 Scientific Papers Day, Nazareth College, November 1, 2008. (Poster presentation)

  Heather Mulford, Margaret E. Logan, The Synthesis and Analysis of Diarylditellurides and Diaryltellurides from a Series of Ester-Substituted Anilines, 53rd Annual undergraduate Research Symposium of the Rochester Section of the American Chemical Soceity, SUNY Geneseo, Geneseo, April 26, 2008 (Oral presentation)

  Heather Mulford, Margaret E. Logan, The Synthesis and Analysis of Diarylditellurides and Dairyltellurides from a Series of Ester-substittuted Anilines, 22nd National Conference on Undergraduate Research, Salisbury, MD, April 10-12, 2008. (Oral presentation)

  Heather Mulford, Margaret E. Logan, The Synthesis and Analysis fo Diarylditellurides and Diaryltellurides. From a Series of Ester-Substituted Aniline: Impact of Electron Density on the Reaction Chemistry and on the Properties of the Telluride Product, Rochester Academy of Science Fall 2007 Scientific Papers Day, SUNY Geneseo, November 10, 2007. (Poster presentation)

  Makoto Nagahama, Margaret E. Logan, Rey A. Sia, The Synthesis of Cationic Antioxidants and the Evaluation of Their Use as Probes of Oxidative Damage in Yeast Mitochondria, Rochester Academy of Science Fall 2007 Scientific Papers Day, SUNY Geneseo, November 10, 2007. (Poster presentation)

  Cory J. Charbonneau, Margaret E. Logan, Palladium-Catalyzed Reactions of Aryl Chlorides: The Nature of the Catalyst and Extension to Green Solvents, Scholars Day, Suny College at Brockport, Brockport, NY, April 11, 2007. (Oral Presentation)

  Cory J. Charbonneau, Margaret E. Logan, Palladium-Catalyized Reactions of Aryl Chlorides: The Nature of the Catalyst and Extension to Green Solvents, Rochester Academy of Science Fall 2006 Scientific Papers Day, St. John Fisher College, November 4, 2006. (Oral presentation

  Luke J. Laczak, Margaret E. Logan, Rey A. Sia, The Synthesis of Cationic Antioxidants and the Evaluation of Their Use as robes of Oxidative Damage in Yeast Mitochondria, Rochester Academy of Science Fall 2006 Scientific Papers Day, St. John fisher College, November 4, 2006. (Oral Presentation)

  Jacqueline Simson, Margaret E. Logan, Rey A. Sia, “The Synthesis of Amino-Substituted Alkylaryltelluride Phosphonium Salts”, 51st Annual Undergraduate Research Symposium of the Rochester Section of the American Chemical Soceity, SUNY college at Brockport, Brockport, April 22, 2006. (Oral presentation)

  Jacqueline Simson, Margaret E. Logan, Rey A. Sia “The Syntehsis of Amino-Substituted Alkylaryltelluride Phosphonium Salts”, Scholars Day, SUNY College at Brockport, Borckport, NY April 12, 2006. (Oral presentation)

  Jacqueline Simson, Margaret E. Logan, Rey A. Sia, “The Syntehsis of Amino-Substituted Alkylaryltelluride Phosphonium Salts” 20th National Conference on Undergraduate Research, Asheville, NC, April 6-8, 2006. (Oral presentation)

  Jacqueline Simson, Margaret E. Logan, Rey A. Sia, “The Syntehsis of Amino-Substituted Alkylaryltelluride Phosphonium Salts”, Rochester Academy of Science Fall 2005 Scientific Papers Day, Finger Lakes Community College, November 5, 2005. (Poster presentation)

  Jacqueline Simson, Margaret E. Logan, Progress toward the Syntehsis of Cationic Alkylaryl Tellurides”, 50th Annual Undergraduate Research Symposium of the Rochester Section of the American Chemical Society, Nazareth College, April 23, 2005. (Oral presentation)

  Mark Oinen, Margaret E. Logan “The Hydrodehalogenation of Aryl Chlorides Using a Homogeneous Palladium Catalyst”, 19th National Conference on Undergraduate Research, Lexington, VA, April 21-23, 2005. (Oral presentation)

  Jacqueline Simson, Margaret E. Logan, “Progress toward the Syntehsis of Cationic Tellurides”, Scholards Day, SUNY College at Brockport, Brockport, Ny, April 13, 2005. (Oral presentation)

  Mark Oinen, Margaret E. Logan, “A Model System for PCB Remediation Using a Homegeneous Palladium Catalyst System”, Scholars Day, SUNY College at Brockport, Brockport, NY, April 13, 2005. (Oral presenation)

  Mark Oinen, Margaret E. Logan “The Hydrodehalogenation of Aryl Chlorides Using a Homogenous Palladium Catalyst”, Northeast Regional Meeting of the American Chemical Society, Rochester, NY, October 31-November 3, 2004. (Poster presentation)

  Alicia Penna, Margaret E. Logan, “The Antioxidant Properties fo Novel Diaryl Tellurides in a Linoleic Acid Free Radical System”, 49th Annual Undergraduate Research Symposium of the Rochester Section of the American Chemical Society, Roberts Weleyan College, April 24, 2004. (Oral presentation)

  Alicia Penna, Margaret E. Logan, “The Antioxidant Properties of Novel Diaryl Tellurides in a Linoleic Acid Free Radical System”, 18th National Conference on Undergraduate Research”, Indianapolis, IN, April 15-17, 2004. (Oral presentation)

  Alicia Penna, Margaret E. Logan, “The Antioxidant Properties of Novel Diaryl Tellurides in a Linoleic Acid Free Radical System”, Undergraduate Science Research Conference, University of Rochester School of Medicine and Dentistry, November 8, 2003. (Poster presentation)

  Alicia Penna, Margaret E. Logan, “The Antioxidant Properties of Novel Diaryl Tellurides in a Linoleic Acid Free Radical System”, Robert A. Laudise Symposium, Union College, Schenectady, NY, October 11, 2003. (Poster presentation)

  Ahmed Yimam, Margaret E. Logan, “An Efficient Syntehsis of Novel, Electron-Rich Diaryl Telluride Antioxidants”, 49th Annual Undergraduate Research Symposium of the Rochester Section of the American Chemical Society, Roberts Wesleyan College, April 24, 2004. (Oral Presentation)

  Ahmed Yimam, Margaret E. Logan, “An Efficient Synthesis of Novel, Electron-Rich Diaryl Telluride Antioxidants”, 49th Annual Undergraduate Research Symposium of the Rochester Section of the American Chemical Society, Roberts Wesleyan College, April 24, 2004. (Oral presentation)

  Ahmed Yimam, Margret E. Logan, “An Efficient Syntehsis of Novel, Electron-Rich Diaryl telluride Antioxidants”, 18th National Conference on Undergraduate Research”, Indianapolis, IN, April 15-17, 2004. (Oral presentation)

  Ahmed Yimam, Margaret E. Logan, “An Efficient Synthesis of Novel, Electron-Rich Diaryl Telluride Antioxidants”, Undergraduate Science Research Conference, University of Rochester School of Medicine and Dentistry, November 8, 2003. (Poster presentation)

  Stacy Morill, Margaret E. Logan, “Progress Toward an Improved Syntehtic Route for Amino-Substituted iaryl Tellurides”, 17th National Conference on Undergraduate Research”, Salt Lake City, Utah, March, 2003 (Oral presentation)

  Stacy Morill, Margaret E. Logan “Progress Toward an Improved Syntehtic Route for Amino-Substituted Diaryl Tellurides”, Undergraduate Scicence Research Conference, University of Rochester School of Medicine and Dentistry, October, 2002 (Poster presentation)

  Andrea N. Topolnycky, Margaret E. Logan, “Synthesis and Evaluation of Novel Diaryl Tellurides, ”17th National Conference on Undergraduate Research”, Salt Lake City, Utah, March, 2003. (Oral presentation)

  Andrea N. Topolnycky, Margaret E. Logan, “ Syntehsis and Evaluation of Novel Diaryl Tellurides”, Undergraduate Science Research Conference, University of Rster School of Medicine and dentistry, October, 2002. (Poster presentation)

  Elizabeth A. Gregory, “ An Improved Synthesis of Amino-Subsittuted Diaryl Telluries”, Scholars Day, SUNY College at Brockport, Brockport, NY, April, 2002. (Oral presentation)

  Elizabeth A. Gregory, Margaret E. Logan, “ An Improed Syntehsis of Amino-Subsittuted Diaryl Tellurides”, 47th Annual Undergraduate Research Symposium of the Rochester Section of the American Chemical Society, Hobart and William Smith Colleges, Geneva, NY, April, 2002. (Oral presentation)

  Elizabeth A. Gregory, Margaret E. Logan, “ An Improved Synthesis of Amino-Substituted Diaryl Tellurides”, 2002 National Conference on Undergraduate Research, Whitewater, Wisconsin, April, 2002. (Oral presentation)

  Elizabeth A. Christensen, Margaret E. Logan, ” An Improved Syntehsis of Amino-Substituted Diaryl Tellurides”, 2002 National Conference on Undergraduate Research, Whitewater, Wisconsin, April, 2002.(Oral presentation)

  Elizabeth A. Christensen, Margaret. E. Logan, ”An Improved Syntehsis of Amino-Substituted Diaryl Tellurides,” Robert A. Laudise Symposium, Union College, Schenectady, NY, September, 2001. (Poster presentation)

  Zachary J. Henneman, Margaret E. Logan, “Progress Toward the Syntehsis of a Water-soluble Julolidine”, 46th Annual Undergraduate Research Symposium of the Rochester SEction of the American Chemical Society, Rochester Institute of Technology, Rochester, NY, april 2001. (Poster presentation)

  Ian B. Hamlet, M. E. Logan, “Synthesis of Electorn-Rich Diaryl Tellurides as Antioxidants” 45th Annual Undergraduate Research Symposium of the Rochester Section of the American Chemical Society, University of Rochester, Rochester, NY, April 200. (Poster presentation)

  John J. Thomas, Margaret E. Logan, “The Synthesis of Water-Soluble Derivatives of Julolidine”, 45th Annual Undergraduate Research Symposium of the Rochester Section of the American Chemical Society, University of Rochester, Rochester, NY, April 2000. (Poster presentation)

  John J. Thomas, Margaret E. Logan, “The Synthesis of Water-soluble Derivatives of Julolidine”, 45th Annual Undergraduate Research Symposium of the Rochester SEction of the American Chemical Society, University of Rochester, Rochester, NY, April 2000. (Poster presentation)

  Timothy Frade, Wayne W. Weber, Margaret E. Logan, Kay Turner, “The Synthesis of Calcium-Selective Chromoionophores”, 38th Annual Undergraduate Research Symposium of the Rochester Section of the American Chemical Society, SUNY College at Brockport, Brockport, NY, April 1993. (Poster presentation)

Professional Service

College Service

• Center for Excellence in Teaching and Learning (CELT) Advisory Committee (Fall 2005-present)
• SciFinder Scholar Coordinator (Summer 2004-present).
• Department of Chemistry Curriculum Committee (Fall 2003-present).
• Pre-Health Professions Advisory Committee (Fall 2002-present).
• Department of Chemistry Equipment and Instrumentation Committee (member: Fall 2000-present; Chair: Fall 2003-present).
• Department of Chemistry Library Coordinator (Fall 2000-present).

Additional Professional Service

• Reviewer: Journal of Organic Chemistry; Organic Letters.
• Co-organizer, 48th Annual Undergraduate Research Symposium of the Rochester Section of the American Chemical Society, SUNY Brockport, April 26, 2003
• Organizer and chair, “Molecular Recognition” plenary session for the 1995 Northeast Regional Meeting of the American Chemical Society
• First chair of the Organic Chemistry Technical Council at the Eastman Kodak Company (1993).
• Co-organizer, Eastman Kodak’s 81st Interplant Technical Conference (1990).
• Harrison Howe Committee for the Rochester Section of the American Chemical Society (1989).
• Developed and Coordinated the Ortho-Clinical Diagnostics program for “Science Saturdays at the Rochester Museum and Science Center” (1996-1998)

Resources Obtained

• (2006) PI, Merck/AAAS Undergraduate Science Research Program proposal; funded in 2006 ($60,000).
• (2005) SUNY Brockport Scholarly Incentive Award of $500, “ Green Chemistry for Dechlorination: A Model System for PCB Detoxification” ($500).
• (2005) Donation by Ortho-Clinical Diagnostics to provide a vibration damper for the Nuclear Resonance Spectrometer, recently funded through NSF CCLI A&I ($5,000).
• (2004) Co-PI, National Science Foundation CCLI Grant for 300 MHz NMR spectrometer($ 127,201).
• (2002) Ortho-Clinical Diagnostics grant for support of a summer 2002 research student ($4,000).
• (2002) Donation of Vented Balance Safety Enclosure and electronic balance by Wyeth-Lederle Vaccines, $2,000 total value.

Professional Organizations

• American Chemical Society (1977 - present)
• Organic Chemistry Division
• Medicinal Chemistry Division
• Division of Chemical Education