Laurie B Cook

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Laurie B Cook , Ph.D

(She/Her/Hers)

Professor (Biology)

(585) 395-5757
lcook@brockport.edu
Office: Lennon Hall 227
Office Hours:

Spring 2023 Course Advisement in 227 Lennon Hall

• Wednesdays 2:30-3:30pm In-Person 
• Wednesdays 3:30-5pm on Zoom (email me for link)
• Fridays 8:30-10am In-Person 

Spring 2023 Pre-professional Health Office Hours In-Person or on Zoom in 123 Smith Hall

• Fridays 12:30-4pm

Bio

Dr. Cook earned her PhD in Pharmacology and Physiology from the University of Rochester Medical Center under the mentorship of Dr. Patricia M. Hinkle.  After a short Postdoc at Cornell University in Molecular Biology & Genetics, she joined the SUNY Brockport Faculty in 2005.  In addition to teaching several required and elective courses to our majors, Dr Cook serves as Director of the Pre-professional Health Program. She is an active researcher and scholar and  has previously held external research grants from both the NSF and NIH totaling over $750K.  

Education

Graduate Certificate · Higher Education Administration · Stonybrook University State University of New York, Online Program 2016

Ph.D. · Pharmacology & Physiology · University of Rochester Medical Center, Rochester, New York 2004

M.S. · Pharmacology & Physiology · University of Rochester Medical Center, Rochester, New York 2001

B.S. · Biochemistry & Molecular Biology · The University at Albany, State University of New York, Albany, New York 1998

Courses Taught

Current courses: General Biology I w/lab (BIO201), Biological Chemistry Lecture (BIO310) and Lab (BIO311), Cancer Biology (BIO475/575), Advanced Cell Biology (BIO407/507), General Endocrinology (BIO466.566), Intro Honors Research (BIO290), Honors Research (BIO493), Honors Thesis (BIO497),Health Professions Shadowing (PPH300)

Research Interests

Using cell culture models of obesity, we hope to gain a foundational understanding of how adipocytes are triggered to expand and differentiate during adipose tissue development.  We are particularly interested in the role that an appetite-stimulating hormone called MCH plays in these decisions, as well as in the recruitment of immune cells like macrophages to adipose tissue, where they can contribute to an inflammatory state. Current student projects include the following:

• Brock Johnston ~ Establishment of a Co-culture Model System for Studying 3T3-L1 Adipocytes and Macrophages
• Colin Johnston ~ Isolation of Lipid Droplets for Biochemical Analysis
• Derek Hutchings (Summer Research Student) & Monite Jolivet ~ A Hypothesis: MCHR1 signals to Actin Filaments in 3T3-L1 cells via Arf6 and Arno
• Kayla Young ~ An Extended mRNA Expression Study in Developing Adipocytes: Lcn2

• Awards/Recognitions
  • SUNY Chancellor’s Award for Excellence in Faculty Service · 2021
  • Nomination for Outstanding Service Award · 2019
  • Discretionary Salary Award for Service · 2011, 2015, 2018, 2019, 2020, 2021
  • Recognition of Support for Students with Disabilities, Brockport · 2015
  • Discretionary Salary Award in Scholarship · 2009, 2010, 2014, 2016
  • Ronald-Fontaine Award for Faculty-Student Engagement, Brockport · 2015
  • Meritorious Service Award, Sigma Delta Epsilon Graduate Women in Science · 2014
  • Travel Award, American Society for Cell Biology · 2014
  • Best Poster Award, Graduate Women in Science · 2012
  • Academic Advisement Award · 2009
  • UUP Professional Development Award · 2008
  • Discretionary Salary Award in Teaching · 2006

• Recent Publications

  * Undergraduate Student Co-Authors

  **Masters Student Co-Authors

  Cook LB, Ophardt, H.D., Galbier, L., Shen, R. Transcriptome analysis of ciliary-dependent MCH signaling in differentiating 3T3-L1 pre-adipocytes. 2021. Sci Rep 11, 4880. https://doi.org/10.1038/s41598-021-84138-4 PMID: 33649390

  Shen R, *Soeder, RA, **Ophardt HD, **Giangrasso, PJ and Cook LB. Identification of Long Non-coding RNAs Expressed in Early Adipogenesis. 2019. OnLine J Biol Sci. https://pdfs.semanticscholar.org/6afc/9411a170aeb663dc3e5b9eeba001f3bdc7c2.pdf

  *Howard AX, *Elnicki R, *Smith AH, *Galardi J, *Thomas-Ibitoye M, *Cohen K, Cook LB, Sreenilayam B. Isolation of Full-Length Wild-Type LGN Protein. 2018. Vol. IX. page 8. Fort Collins, CO: Journal of Undergraduate Research and Scholarly Excellence. www.jurpress.org

  **Moden JI, *Haude K, *Carroll R, **Goodspeed A, Cook LB. Analyzing the Role of Receptor Internalization in the Regulation of Melanin-concentrating Hormone Signaling. Int J Endocrin. Vol 2013, Article ID 143052, 10 pages, 2013. PMID: 24348551

  Cook LB, *Shum L, **Portwood, S. Melanin-concentrating Hormone Facilitates Migration of 3T3-L1 Preadipocytes. Mol Cell Endo. 2010. 320:45-50. PMID: 2017126

  Cook LB, **Delorme-Axford EB, *Robinson, K. Caveolae as potential mediators of MCH-signaling pathways. Biochem. Biophys. Res. Comm. 2008 Oct 31; 375:592-595. PMID: 18722347

• Presentations

  Recent Collaborations with Students:

  Colin Johnston (B.S. ’25) Biochemical Isolation of Lipid Droplets from 3T3-L1 Adipocytes presented at the Rochester Academy of Sciences Fall Paper Session, Rochester Museum and Science Center, November 2022.

  Brock Johnston (B.S. ’23) Determination of MCH Receptors in J774A.1 Macrophages. presented at the Rochester Academy of Sciences Fall Paper Session, Rochester Museum and Science Center, November 2022.

  Derek Hutchings (B.S. ’23) Arf-6 Movement in Response to MCH Treatment in 3T3-L1 Cells presented at SUNY Brockport’s SURP Poster Session, Drake Library, October 2022.

External Grant Funding

2015-2019 - RUI: Adaptation of MCH receptor function during differentiation of adipocytes · The  National Science Foundation · Principal Investigator · Grant Number 1515737 · $404,344 ·Major Goal: To determine the role of primary cilia in the regulation of MCHR1 signaling in differentiating 3T3-L1 adipocytes.

2016-2017 - RUI: Adaptation of MCH receptor function during differentiation of adipocytes · The  National Science Foundation · Principal Investigator · Grant Number 1515737 · $4,000 ·Major Goal: Summer Graduate Student Stipend

2010-2014 - NIH R15 AREA: An Investigation into the Molecular Mechanisms of Melanin-concentrating  Hormone Receptor Desensitization · NIH/NIGMS · Principal Investigator · Grant Number 1R15GM090163 · $211,783· Major Goal: To determine the roles of caveolae, beta-arrestin recruitment and receptor degradation to the regulation of MCH signaling.

2010-2011 - NIH R15 AREA: An Investigation into the Molecular Mechanisms of Melanin-concentrating  Hormone Receptor Desensitization - Supplement · NIH/NIGMS · Principal Investigator ·Grant Number 1R15GM090163 · $36,132 · Major Goal: To fund the purchase of a fluorescence plate reader to facilitate the aims associated with 1R15GM090163-01.

Professional Memberships

• National Association of Health Professions Advisors
• State University of New York Council for University Advancement
• American Society for Pharmacology & Experimental Therapeutics
• National Society for Experiential Education
• Rochester Academy of Sciences
• The American Society for Cell Biology